Understanding and Controlling Living/Inorganic Interfaces to Enable Reconfigurable Switchable Materials

Report No. ARL-TR-8312
Authors: Margaret M Hurley, Hong Dong, Justin Jahnke, Deborah Sarkes, Meagan Small, Dimitra Stratis-Cullum, Jessica Terrell, and Nicole Zander
Date/Pages: March 2018; 22 pages
Abstract: Results are highlighted for a 3-year study to study fundamental interactions between engineered E. coli cells and inorganic surfaces (gold and functionalized silica) to develop tailored, switchable bacterial adhesion to a target surface. This work includes protein engineering of multiple targets (FimH and eCPX), a variety of analytical techniques (including scanning electron microscopy and atomic force microscopy), theoretical models including multiphysics and multiscale treatments, as well as one of the first known studies of the role of environmental conditions and surface treatment on binding affinity.
Distribution: Approved for public release
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Last Update / Reviewed: March 1, 2018