A Computational Model of Soman-Induced Cardiac Toxicity (I): Simulation at the Cellular Level

Report No. ARL-TR-2367
Authors: Zoltani, Csaba K.; Baskin, Steven I.
Date/Pages: November 2000; 60 pages
Abstract: Under a memorandum of understanding (MOU) between the Computational and Information Sciences Directorate (formerly the Corporate Information and Computing Directorate) of the U.S. Army Research Laboratory and the U.S. Army Medical Research Institute of Chemical Defense, results of a study to model the electrophysiological changes in the heart due to soman toxicity are reported. This, the first of a series of reports, presents a computational model of cardiac toxicity at the cellular level and shows the changes in electrical activity for a series of organophosphate (OP) dose concentrations expressed by changes in the acetylcholine concentration generated membrane currents. A plausibility argument is advanced for the consideration of an overlooked aspect of the problem, the effect of extracellular potassium ion accumulation, to the understanding of soman-induced electrophysiological chaos.
Distribution: Approved for public release
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Last Update / Reviewed: November 1, 2000