Advances in Synthetic Peptides Reagent Discovery

Report No. ARL-RP-0451
Authors: Bryn L. Adams, Deborah A. Sarkes, Amethist S. Finch, and Dimitra N. Stratis-Cullum
Date/Pages: July 2013; 16 pages
Abstract: Bacterial display technology offers a number of advantages over competing display technologies (e.g, phage) for the rapid discovery and development of peptides with interaction targeted to materials ranging from biological hazards through inorganic metals. We have previously shown that discovery of synthetic peptide reagents utilizing bacterial display technology is relatively simple and rapid to make laboratory automation possible. This included extensive study of the protective antigen system of Bacillus anthracis, including development of discovery, characterization, and computational biology capabilities for in-silico optimization. Although the benefits towards CBD goals are evident, the impact is far-reaching due to our ability to understand and harness peptide interactions that are ultimately extendable to the hybrid biomaterials of the future. In this paper, we describe advances in peptide discovery including, new target systems (e.g. non-biological materials), advanced library development and clone analysis including integrated reporting.
Distribution: Approved for public release
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Last Update / Reviewed: July 1, 2013