Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid Muscle Inhibition

Report No. ARL-CR-0783
Authors: Cameron H Good
Date/Pages: September 2015; 24 pages
Abstract: The sublaterodorsal (SLD) nucleus is hypothesized to induce muscle atonia during rapid eye movement (REM) sleep. This was tested by injecting channelrhodopsin into the SLD of 5 rats, followed by a series of behavioral tests. Results confirmed our ability to rapidly induce muscle atonia following optogenetic stimulation of the SLD, suggesting that activation of the SLD is sufficient to cause a REM atonia like state.
Distribution: Approved for public release
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Last Update / Reviewed: September 1, 2015