In Silico Methods Shed New Insights Into Cyanide-Caused Cardiac Toxicity

Report No. ARL-TR-3485
Authors: Csaba K. Zoltani, Steven I. Baskin, and COL G. E. Platoff
Date/Pages: May 2005; 26 pages
Abstract: A high performance computational study of cyanide's (CN's) effect on cardiac tissue is presented. CN's interference with atrial tissue energy production was simulated by studying the effect of the changes in magnitude of the KATP membrane current on the action potential, thereby understanding the processes leading to the disappearance of the P-wave in the CN-affected tissue. CN was found to render the membrane current levels insufficient to maintain the required wave shape and duration. These results suggest that pharmacological intervention could seek the restoration of ion concentration levels as a possible approach to restoring homeostasis.
Distribution: Approved for public release
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Last Update / Reviewed: May 1, 2005