Genetically Engineered Peptides for Inorganics: Study of an Unconstrained Bacterial Display Technology and Bulk Aluminum Alloy

Report No. ARL-RP-0457
Authors: Bryn L. Adams, Amethist S. Finch, Margaret M. Hurley, Deborah A. Sarkes, and Dimitra N. Stratis-Cullum
Date/Pages: September 2013; 18 pages
Abstract: ARL researchers report on a 6.1 research breakthrough in an article highlighted on the inside front cover of the Sept. 6th issue of Advanced Materials (impact factor 14.829). This journal is the premier material science journal, featuring interdisciplinary research at the cutting edge of the chemistry and physics of functional materials. Using the showcased technology, scientists can now develop high affinity materials without knowing anything about the binding site or chemistry of the targeted surface. The ARL researchers are the first to show that sequence-dependent, structure-function relationships of "designer" peptides with metal and metal oxide materials contribute to high affinity peptide interactions. The basic knowledge obtained by this and related ongoing research is critical to a wide spectrum of Army applications that require hybrid (bio/non-bio) integration. Moreover, this work aligns with the emerging field of synthetic biology and synthetic molecular systems identified as one of several strategic research areas for future game-changing capabilities to our Soldiers in the recent RDECOM strategy document Maximizing Land Combat Power.
Distribution: Approved for public release
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Last Update / Reviewed: September 1, 2013